Results
| PMID | 25194152 |
| Gene Name | KITLG |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 60 |
| Population details | 60 (35 women with endometriosis, 25 fertile eumenorrheic women) |
| Sex | Female |
| Associated genes | Ki67, SCF, Akt, GSK3B |
| Other associated phenotypes |
Endometriosis |
|
Reprod Sci. 2015 Apr;22(4):502-10. doi: 10.1177/1933719114549843. Epub 2014 Sep Franco-Murillo, Yanira| Miranda-Rodriguez, Jose Antonio| Rendon-Huerta, Erika| Montano, Luis F| Cornejo, Gerardo Velazquez| Gomez, Lucila Poblano| Valdez-Morales, Francisco Javier| Gonzalez-Sanchez, Ignacio| Cerbon, Marco Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico, Federal District, Mexico.| Unidad de Endoscopia e Infertilidad, Hospital de la Mujer, Secretaria de Salud, Mexico, Mexico.| Departamento Biologia Celular y OBJECTIVE: Endometriosis is linked to altered cell proliferation and stem cell markers c-kit/stem cell factor (SCF) in ectopic endometrium. Our aim was to investigate whether c-kit/SCF also plays a role in eutopic endometrium. DESIGN: Eutopic endometrium obtained from 35 women with endometriosis and 25 fertile eumenorrheic women was analyzed for in situ expression of SCF/c-kit, Ki67, RAC-alpha serine/threonine-protein kinase (Akt), phosphorylated RAC-alpha serine/threonin-protein kinase (pAkt), Glycogen synthase kinase 3 beta (GSK3beta), and phosphorylated glycogen synthase kinase 3 beta (pGSK3beta), throughout the menstrual cycle. RESULTS: Expression of Ki67 and SCF was higher in endometriosis than in control tissue (P < .05) and greater in secretory rather than proliferative (P < .01) endometrium in endometriosis. Expression of c-kit was also higher in endometriosis although similar in both phases. Expression of Akt and GSK3beta was identical in all samples and cycle phases, whereas pAkt and pGSK3beta, opposed to control tissue, remained overexpressed in the secretory phase in endometriosis. CONCLUSION: Unceasing cell proliferation in the secretory phase of eutopic endometriosis is linked to deregulation of c-kit/SCF-associated signaling pathways. Mesh Terms: Adult| Biopsy| Case-Control Studies| *Cell Proliferation| Endometriosis/*enzymology/pathology/physiopathology| Endometrium/*enzymology/pathology/secretion| Female| Glycogen Synthase Kinase 3/*analysis| Glycogen Synthase Kinase 3 beta| Humans| Im |
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